Novel Therapeutics

CMLase, also referred to in scientific literature as CMLAS or CML-deglycase, is an engineered bacterial-derived enzyme developed through a collaboration between Revel Pharmaceuticals, Calico Life Sciences, and the University of Colorado Anschutz Medical Campus. Published in Nature Communications by Trabosh et al. in 2026, this enzyme represents a novel therapeutic approach targeting advanced glycation end products and cellular senescence. CMLase functions by cleaving carboxym

Alpha-Linolenic Acid is a plant-derived omega-3 fatty acid, serving as nature's essential precursor for the long-chain omega-3s EPA and DHA. As a critical component of cell membranes and a key player in cardiovascular and metabolic health, it represents the primary dietary source of omega-3 for plant-based populations and a vital building block for systemic well-being. 1. Overview: Alpha-linolenic acid (ALA) is an 18-carbon polyunsaturated fatty acid (PUFA) belonging to the o

DHA is a foundational long-chain omega-3 fatty acid, revered as the building block of the human brain and retina. It serves as the primary structural lipid in neural and retinal membranes, orchestrating cognitive development, synaptic plasticity, and visual acuity, while also playing critical roles in neuroprotection and the resolution of inflammation. 1. Overview: Docosahexaenoic acid (DHA) is a 22-carbon polyunsaturated fatty acid (PUFA) belonging to the omega-3 family. It