Diagnostic Tests

1. Overview: What this test reveals and why it is important The antinuclear antibody (ANA) test detects autoantibodies directed against components of the cell nucleus. These antibodies target DNA, histones, ribonucleoproteins, and other nuclear antigens. A positive ANA indicates that the immune system has lost tolerance to self‑nuclear material and is producing antibodies that may attack the body's own tissues. This test is the primary screening tool for systemic autoimmune r