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Specialized pro-resolving mediators, or SPMs, are a family of lipid-derived signaling molecules that play a central role in the active resolution of inflammation. They are not immunosuppressive. Instead, they orchestrate the cleanup and repair phases after an inflammatory response. SPMs are gaining recognition for their potential to support tissue healing, reduce chronic inflammation, and restore balance to the immune system. --- 1. Overview Specialized pro-resolving mediator

Historical Foundations and Modern Applications of Ultra-Low-Dose Immunotherapy Low-dose allergen therapy, known as LDA, and its predecessor enzyme-potentiated desensitization, known as EPD, represent a distinctive lineage within the broader field of immunotherapy. These approaches use extremely dilute preparations of allergens and other biological substances, combined with an enzyme catalyst, to modulate immune responses and reduce hypersensitivity. Developed over half a cent

The Deeper Science, the Living Context, and the Road to Legitimacy The first part of this essay traced the history of enzyme-potentiated desensitization and its modern descendant, low-dose allergen therapy. We explored the origins of the approach in Leonard McEwen's work, the basic immunological principles that might explain its effects, the practical methodology, and the current state of the evidence. We also acknowledged the significant challenges that have kept these thera